Transcriptional response of bovine macrophages after infection with two Argentinean Mycobacterium bovis isolates

ABSTRACT: Infection of cattle with Mycobacterium bovis causes severe financial hardship in many countries, in addition to presenting a health risk for humans. As an intracellular pathogen, M. bovis, adapted to survive and thrive within the intramacrophage environment. However, little is known about expression patterns in the macrophage, particularly in the bovine host. In this study, DNA microarray analysis was used to detect genes expressed in Holstein bovine macrophages derived from peripheral blood mononuclear cells infected during four hours with two Argentinean strains of M. bovis, a virulent strain, 04-303 and an attenuated strain, 534. Genes encoding antrax toxin receptor, cell division and apoptosis regulator, ankyrin proteins that are found within the membrane associated cytoskeleton, prote

ORGANISM(S): Bos taurus

SUBMITTER: Marcelo Soria 

PROVIDER: E-GEOD-39819 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress