Genome-wide analysis of macrophage gene expression upon Bcl3 knockdown

ABSTRACT: By binding to specific DNA elements, known collectively as “κB sites”, contained within the promoters/enhancers of target genes, NF-κB regulates gene expression. We found that the identity of the central base pair (bp) of κB sites profoundly impacts the transcriptional activity of NF-κB dimers. RelA dimers prefer an A/T bp at this position for optimum transcriptional activation (A/T-centric) and discriminate against G/C-centric κB sites. The p52 homodimer, in contrast, activates transcription from G/C-centric κB sites in complex with Bcl3 but represses transcription from the A/T-centric sites. The p52:Bcl3 complex binds to these two classes of κB sites in distinct modes permitting recruitment of coactivator, corepressor, or both coactivator and corepressor complexes in promoters contain

ORGANISM(S): Mus musculus

SUBMITTER: Vivien Wang 

PROVIDER: E-GEOD-39922 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress