Blood transcriptome of human bacterial and influenza A pneumonia

ABSTRACT: Introduction: Diagnosis of severe influenza pneumonia remains challenging because of the lack of correlation between presence of influenza virus and patient’s clinical status. We conducted gene expression profiling in the whole blood of critically ill patients to identify a gene signature that would allow clinicians to distinguish influenza infection from other causes of severe respiratory failure (e.g. bacterial pneumonia, non-infective systemic inflammatory response syndrome). Methods: Whole blood samples were collected from critically ill individuals and assayed on Illumina HT-12 gene expression beadarrays. Differentially expressed genes were determined by linear mixed model analysis and over-represented biological pathways determined using GeneGo MetaCore. Results: The gene express

ORGANISM(S): Homo sapiens

SUBMITTER: Grant Parnell 

PROVIDER: E-GEOD-40012 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress