Transcription profiling of human patients suffering FROM bacterial infections TO investigate plasticity OF THE systemic inflammatory response TO acute infection during critical illness

ABSTRACT: Diagnosis of acute infection in the critically ill remains a challenge. Changes in physiologic parameters and existing molecular diagnostics are not specific and microbiologic confirmation of infection can take days. As cellular first responders, preclinical studies indicate that circulating leukocytes are activated in response to bacterial infection, manifesting infection-specific transcriptional programs. We hypothesized that circulating leukocyte transcriptional profiles can be used to diagnose infection and monitor response to therapy in the critically ill. Experiment Overall Design: A translational research approach was employed. Fifteen mice underwent intratracheal (i.t.) injections of live P. aeruginosa, P. aeruginosa endotoxin, live S. pneumoniae, or normal saline. At 24 hours af

ORGANISM(S): Homo sapiens

SUBMITTER: J Perren Cobb 

PROVIDER: E-GEOD-6377 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress