Multiple roles of RNase Y in Streptococcus pyogenes mRNA metabolism

ABSTRACT: Streptococcus pyogenes (Group A streptococcus, GAS) is an important human pathogen that causes a variety of infectious diseases and sequelae. Recent studies showed virulence factor expression was controlled at multiple levels, including the post-transcriptional regulation. In this study, we examined the global half-lives of S. pyogenes mRNAs and explored the role RNase Y played in mRNA metabolism with microarray analysis. key word: genetic modification Streptococcus pyogenes NZ131 wild-type cells and ?rny strains were grown in C-medium until late exponential phase. Rifampicin was added to the cell culture and samples were collected before and after rifampicin addition. The transcriptional profile of the whole genome before and after rifampicin addition was examined with microarray. Please

ORGANISM(S): Streptococcus pyogenes

SUBMITTER: Jens Kreth 

PROVIDER: E-GEOD-40198 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress