Transcription profiling of mouse innate immune response of nasal-associated lymphoid tissue (NALT) to Streptococcus pyogenes infection.

ABSTRACT: Streptococcus pyogenes is a major causative agent of tonsillitis or pharyngitis in children, which can lead to more invasive infections and noninfectious sequellae. S. pyogenes can persist in tonsils, while one-third of children treated with antibiotics continue to shed streptococci and have recurrent infections. Mouse nasal-associated lymphoid tissue (NALT) is functionally analogous to human oropharangeal lymphoid tissues. The innate immune responses of naïve cells from a mucosal site to S. pyogenes is not well described; therefore, we infected C57BL/6 mice intranasally with 108 CFU S. pyogenes. Transcriptional responses by NALT after S. pyogenes infection were analyzed by Affymetrix microarray and quantitative RT-PCR. Wild-type S. pyogenes induces transcription of both type I and IFN-g

ORGANISM(S): Mus musculus

SUBMITTER: Ellen Murphy 

PROVIDER: E-GEOD-11494 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress