Interferon-gamma Induced Gene Expression Changes in Human Neutrophils

ABSTRACT: The cytokine interferon-gamma (IFN-gamma) is used as a drug to treat Chronic Granulomatous Disease (CGD), a group of genetic disorders characterized by defects in components of the neutrophil-resident NADPH oxidase/Nox2 enzyme system. Administration of IFN-gamma to these patients results in decreased incidents of severe infection, but has no effect on the characteristic defect of CGD, the inability to convert oxygen to microbicidal reactive oxygen species. To determine the mechanism by which IFN-gamma enhances the host protective properties of neutrophils, we administered INF-gamma to 10 healthy adult volunteers and carried out transcription profiling by array for neutrophils isolated from their peripheral blood. IFN-gamma was administered to each subject at 4 doses (10, 25, 50 and 100

ORGANISM(S): Homo sapiens

SUBMITTER: Michael Ellison 

PROVIDER: E-MTAB-7261 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress