Nucleosome positioning in A549 cells before/after NME2 induction

ABSTRACT: Previous studies have analyzed patterns of transcription, transcription factor (TF) binding or mapped nucleosome occupancy across the genome. These suggest that the three aspects are genetically connected but the cause and effect relationships are still unknown. For example, physiologic TF binding studies involve many TFs, consequently, it is difficult to assign nucleosome reorganization to the binding site occupancy of any particular TF. Therefore, several aspects remain unclear: does TF binding influence nucleosome (re)organizations locally (in close vicinity of their binding sites) or impact the chromatin landscape at a more global level; are all or only a fraction of TF binding a result of reorganization in nucleosome occupancy; finally, do all TF binding and associated nucleosome occ

ORGANISM(S): Homo sapiens

SUBMITTER: Vinod Yadav 

PROVIDER: E-GEOD-40363 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress