RNA-Seq profiling unveils a non-canonical Wnt signalling signature in pancreas versus liver fate decision

ABSTRACT: Understanding how distinct cell types arise from common multipotent progenitor cells is a major quest in stem cell biology. This knowledge will aid in the targeted differentiation and growth of stem cells, but also in the discovery of the basis of cellular plasticity and of how tissue programming can be controlled. The liver and pancreas share many aspects of their early development, being both specified in the same region of the endoderm, and, possibly, originating from a common progenitor. However, how pancreas versus liver cell fate decision occurs during embryogenesis and the molecular basis of this cellular plasticity are poorly understood. Here, we use RNA-Seq to define the molecular identity of liver and pancreas progenitors directly in mouse embryos and to investigate the mechanism

ORGANISM(S): Mus musculus

SUBMITTER: Francesca Spagnoli 

PROVIDER: E-GEOD-40823 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress