Steroid-induced changes in gene expression of airway smooth muscle in patients with asthma

ABSTRACT: Rationale: Steroids are the mainstay of asthma therapy. However, it is unclear whether the benefits of steroids in asthma are merely based on anti-inflammatory properties. Steroids may also alter gene expression of airway smooth muscle (ASM). Hypothesis and Aims: We hypothesized that the transcriptomic profile of the ASM layer in endobronchial biopsies of atopic asthma patients changes by oral steroid therapy. First, we examined the change in ASM transcriptomic profile in endobronchial biopsies after 14 days of oral steroid therapy. Second, we investigated the association between changes in ASM transcriptomic profile and airway function. Methods: 12 atopic steroid-free asthma patients were included in this double-blind intervention study. Endobronchial biopsies were taken before and after

ORGANISM(S): Homo sapiens

SUBMITTER: Ching Yong Yick 

PROVIDER: E-GEOD-40996 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress