Comparative Genome-Wide Transcriptional Analysis of Bilateral Internal Mammary Arteries

ABSTRACT: In Coronary Artery Bypass Grafting (CABG), the combined use of Left or Right Internal Mammary Artery (LIMA or RIMA) -collectively known as Bilateral IMAs (BIMAs)- provides a survival advantage over the LIMA alone. Several studies analyzed the gene expression in LIMAs and other conduits, however they either used a candidate gene approach or analyzed a small number of samples. Additionally, RIMA has never been analyzed compared to LIMA. Here we report a genome-wide transcriptional analysis of BIMA to investigate the expression profile of these conduits in patients undergoing CABG. Marginal differences were reported between LIMA and RIMA (p <0.05) using a linear model for microarray data. Ingenuity Pathway Assist (IPA) analysis found no consistent set of over-represented pathways and no trend

ORGANISM(S): Homo sapiens

SUBMITTER: Lan Hu 

PROVIDER: E-GEOD-41036 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress