Proteomics

Dataset Information

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Human PVAT and SubQ whole adipose from CABG and VR patients

ABSTRACT: Perivascular adipose (PVAT and subcutaneous adipose tissue (SubQ) from donors undergoing mitral valve repair/replacement (VR) and coronary artery bypass graft (CABG) surgeries were analyzed. There are 3 SWATH data sets. The first contains CABP PVAT, CABG SubQ, VR PVAT, and VR SubQ. The second includes only CABG PVAT from donors with and without diabetes. The third set includes CABG PVAT and SubQ and VR PVAT. Additionally, there are multiple reaction monitoring data sets comparing CABG PVAT with and without diabetes, CABG SubQ with and without diabetes, CABG PVAT to CABG SubQ both without diabetes, CABG PVAT to CABG SubQ both with diabetes, and CABG PVAT without diabetes to VR PVAT without diabetes.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Fat Cell, Adipose Tissue

DISEASE(S): Coronary Artery Disease

SUBMITTER: Carlos Gartner  

LAB HEAD: Calvin Vary

PROVIDER: PXD051676 | Pride | 2025-05-06

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
gg_ks_100121_CABG105P_IDA_00001.wiff Wiff
gg_ks_100121_CABG105P_IDA_00001.wiff.scan Wiff
gg_ks_100121_CABG105P_IDA_0001.wiff Wiff
gg_ks_100121_CABG105P_IDA_0001.wiff.scan Wiff
gg_ks_100121_CABG105P_IDA_001.wiff Wiff
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Publications

Cellular Characteristics and Protein Signatures of Human Adipose Tissues from Donors With or Without Advanced Coronary Artery Disease.

Ellis Caitlin P S CPS   Tero Benjamin W BW   Potts Christian M CM   Malka Kimberly T KT   Yang Xuehui X   Hamilton Joshua J   Vary Calvin C   Khalil Andre A   Liaw Lucy L  

Biomedicines 20241025 11

<b>Background/Objectives</b>: Perivascular adipose tissue (PVAT) exerts a paracrine effect on blood vessels and our objective was to understand PVAT molecular signatures related to cardiovascular disease. <b>Methods</b>: We studied two groups: those undergoing mitral valve repair/replacement (VR, n = 16) and coronary artery bypass graft (CABG, n = 38). VR donors did not have coronary artery disease, whereas CABG donors had advanced coronary artery disease. Clinical and tissue pathologies and pro  ...[more]

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