FOXO3 in control of circadian rhythms via direct regulation of Clock
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Marian Groot Koerkamp
PROVIDER: E-GEOD-41566 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Insulin-FOXO3 signaling modulates circadian rhythms via regulation of clock transcription.
Chaves Inês I van der Horst Gijsbertus T J GT Schellevis Raymond R Nijman Romana M RM Koerkamp Marian Groot MG Holstege Frank C P FC Smidt Marten P MP Hoekman Marco F M MF
Current biology : CB 20140522 11
Circadian rhythms are responsive to external and internal cues, light and metabolism being among the most important. In mammals, the light signal is sensed by the retina and transmitted to the suprachiasmatic nucleus (SCN) master clock [1], where it is integrated into the molecular oscillator via regulation of clock gene transcription. The SCN synchronizes peripheral oscillators, an effect that can be overruled by incoming metabolic signals [2]. As a consequence, peripheral oscillators can be un ...[more]
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