Clonal evolution and devolution following chemotherapy in adult acute myelogenous leukemia

ABSTRACT: The frequent occurrence of persistent or relapsed disease following induction chemotherapy in AML necessitates a better understanding of the clonal relationship of AML in various disease phases. In this study, we employed SNP 6.0 array-based genomic profiling of acquired copy number aberrations (aCNA) and copy neutral LOH (cnLOH) together with sequence analysis of recurrently mutated genes to characterize paired AML genomes. We analyzed 28 AML sample pairs from patients that achieved complete remission with chemotherapy and subsequently relapsed and 11 sample pairs from patients with persistent disease following induction chemotherapy. Through review of aCNA/cnLOH and gene mutation profiles in informative cases we demonstrate that relapsed AML invariably represents reemergence or evolution

ORGANISM(S): Homo sapiens

SUBMITTER: Sami Malek 

PROVIDER: E-GEOD-41646 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress