Species- and condition-specific adaptation of the transcriptional landscapes in Candida albicans and Candida dubliniensis

ABSTRACT: Although Candida albicans and Candida dubliniensis are most closely related, both species significantly behave differently with respect to morphogenesis and virulence. In order to gain further insight into the divergent routes for morphogenetic adaptation in both species, we investigated qualitative along with quantitative differences in the transcriptomes of both organisms by cDNA deep sequencing. Following genome-associated assembly of sequence reads we were able to generate experimentally verified databases containing 6016 and 5972 genes for C. albicans and C. dubliniensis, respectively. About 95% of the transcriptionally active regions (TARs) contain open reading frames while the remaining TARs most likely represent non-coding RNAs. Comparison of our annotations with publically availab

ORGANISM(S): Candida albicans

SUBMITTER: Kai Sohn 

PROVIDER: E-GEOD-41749 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress