Gene expression profiling in the cerebral cortex of patients with cirrhosis with and without hepatic encephalopathy

ABSTRACT: Hepatic encephalopathy (HE) is a frequent complication of liver cirrhosis and is seen as the clinical manifestation of a low grade cerebral edema associated with oxidative-nitrosative stress, however, comprehensive data on HE-associated molecular derangements in human brain are lacking. In the present study we used a whole human genome micro-array approach for gene expression profiling in post mortem brain samples from cirrhotic patients with or without HE and non-cirrhotic controls. Altered expression levels were found for a total of 1012 genes in liver cirrhotic patients without and with HE and HE-characteristic gene expression changes were identified. Genes with altered expression pattern in HE were related oxidative stress, microglia activation, inflammatory signalling pathways, cellul

ORGANISM(S): Homo sapiens

SUBMITTER: Boris Goerg 

PROVIDER: E-GEOD-41919 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress