Genome-wide analysis of epicardial gene expression in E11.5 mouse hearts

ABSTRACT: Identification of epicardium-enriched genes in the embryonic heart. The epicardium encapsulates the heart and functions as a source of multipotent progenitor cells and paracrine factors essential for cardiac development and repair. Injury of the adult heart results in re-activation of a developmental gene program in the epicardium, but the transcriptional basis of epicardial gene expression has not been delineated. We established a mouse embryonic heart organ culture and gene expression system that facilitated the identification of epicardial enhancers activated during heart development and injury. Epicardial activation of these enhancers depends on a combinatorial transcriptional code centered on CCAAT/enhancer binding protein (C/EBP) transcription factors. Disruption of C/EBP signaling i

ORGANISM(S): Mus musculus

SUBMITTER: Guo Huang 

PROVIDER: E-GEOD-41959 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress