Integration of epigenetic and transcriptional mechanisms governs functional commitment versus plasticity of gd T cell subsets

ABSTRACT: gd T cells are major innate sources of interleukin-17 (IL-17) and interferon-g (IFN-g), which are differentially produced by two thymically-derived subsets segregated on CD27 expression. However, the molecular mechanisms that program the functional differentiation of gd cells remain incompletely understood. Here we show that CD27+ gd cells are epigenetically committed to express Ifng but not Il17, whereas CD27- gd cells spontaneously make IL-17 but can be induced to produce IFN-g under specific inflammatory conditions. This M-bM-^@M-^\plasticM-bM-^@M-^] behavior of CD27- gd cells associates with permissive histone H3 marks at loci encoding Ifng and upstream M-bM-^@M-^\type 1M-bM-^@M-^] transcription factors. By contrast, Il17 and related M-bM-^@M-^\type 17M-bM-^@M-^] factors are epigenetic

ORGANISM(S): Mus musculus

SUBMITTER: Ana Grosso 

PROVIDER: E-GEOD-42098 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress