Unknown,Transcriptomics,Genomics,Proteomics

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Identification of BORIS-bound transcripts in neural progenitor cells and young neurons

ABSTRACT: This study compares the transcripts bound to BORIS in neural progenitor cells and cells differentiated for 6 days into young neurons We present expression profiles for neural progenitor cells (arrays hybridised in triplicate) and in young neurons (arrays hybridised in duplicate). Immunoprecipitated BORIS-mRNA complexes were used to assess the association of BORIS with target mRNAs in neural progenitor cells and in young neurons (both arrays hybridised in duplicate).

ORGANISM(S): Homo sapiens

SUBMITTER: Denise Sheer 

PROVIDER: E-GEOD-42294 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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<h4>Background</h4>BORIS (CTCFL), a paralogue of the multifunctional and ubiquitously expressed transcription factor CTCF, is best known for its role in transcriptional regulation. In the nucleus, BORIS is particularly enriched in the nucleolus, a crucial compartment for ribosomal RNA and RNA metabolism. However, little is known about cytoplasmic BORIS, which represents the major pool of BORIS protein.<h4>Results</h4>We show, firstly, that BORIS has a putative nuclear export signal in the C-term  ...[more]

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