ING4 regulates a secretory phenotype in primary fibroblasts with dual effects on cell proliferation and tumor growth

ABSTRACT: ING proteins play an essential role in the control of a variety of cellular functions whose deregulation is associated with tumor formation and dissemination, such as proliferation, apoptosis, senescence or invasion. Accordingly, loss of function of ING proteins is a frequent event in many types of human tumors. In this report, we have studied the function of ING4, a member of the ING family of tumor suppressors, in the context of normal, non-transformed primary fibroblasts. We show that ING4 negatively regulates cell proliferation in this cell type. The antiproliferative action of ING4 requires its ability to recognize chromatin marks, it is p53-dependent and it is lost in an ING4 cancer-associated mutant. Gene expression analysis shows that ING4 regulates the expression and release

ORGANISM(S): Homo sapiens

SUBMITTER: Gema Moreno-Bueno 

PROVIDER: E-GEOD-42412 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress