Deregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders

ABSTRACT: Studies have shown that HIV-infected patients develop neurocognitive disorders characterized by neuronal dysfunction. The lack of productive infection of neurons by HIV suggests that viral and cellular proteins, with neurotoxic activities, released from HIV-1-infected target cells can cause this neuronal deregulation. The viral protein R (Vpr), a protein encoded by HIV-1, has been shown to alter the expression of various important cytokines and inflammatory proteins in infected and uninfected cells; however the mechanisms involved remain unclear. Using a human neuronal cell line, we found that Vpr can be taken up by neurons causing: (i) deregulation of calcium homeostasis, (ii) endoplasmic reticulum-calcium release, (iii) activation of the oxidative stress pathway, (iv) mitochondrial dysfu

ORGANISM(S): Homo sapiens

SUBMITTER: Bassel Sawaya 

PROVIDER: E-GEOD-42424 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress