Gene expression in the right ventricle of Rattus norvegicus during development of right ventricular heart failure and treatment

ABSTRACT: Right ventricular heart failure (RVF) associated with pulmonary hypertension (PH) is characterized by a distinct gene expression pattern when compared with functional compensatory hypertrophy. Carvedilol treatment after RVF has been established reduces right ventricle (RV) hypertrophy and improves the RV function. In addition, carvedilol treatment has been shown to alter the gene expression of select genes. We sought to identify, on a genome-wide basis, the effect of carvedilol on gene expression. RVF was induced in male Sprague-Dawley rats by the combination of VEGF-receptor blockade and chronic hypoxia; thereafter, one group was treated with carvedilol. RNA was isolated from the RV and subjected to microarray analysis. A prediction analysis of the carvedilol-treated RVs showed tha

ORGANISM(S): Rattus norvegicus

SUBMITTER: Jennifer Drake 

PROVIDER: E-GEOD-42579 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress