Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Early Embryonic Cell, Macrophage
DISEASE(S): Disease Free
SUBMITTER: Elke Hammer
LAB HEAD: Elke Hammer
PROVIDER: PXD026916 | Pride | 2025-08-07
REPOSITORIES: Pride
Action | DRS | |||
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190226_OV4_UL_DZHKe_BM_J1.raw | Raw | |||
190226_OV4_UL_DZHKe_BM_J2.raw | Raw | |||
190226_OV4_UL_DZHKe_BM_J3.raw | Raw | |||
190226_OV4_UL_DZHKe_YS_J1.raw | Raw | |||
190226_OV4_UL_DZHKe_YS_J2.raw | Raw |
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Cells 20211217 12
<h4>Background</h4>Tissue-resident macrophages have mixed developmental origins. They derive in variable extent from yolk sac (YS) hematopoiesis during embryonic development. Bone marrow (BM) hematopoietic progenitors give rise to tissue macrophages in postnatal life, and their contribution increases upon organ injury. Since the phenotype and functions of macrophages are modulated by the tissue of residence, the impact of their origin and developmental paths has remained incompletely understood. ...[more]