Transcriptomic comparison of 5 cell types during lethal and non-lethal influenza infection

ABSTRACT: Transcriptomic comparison of 5 cell types during lethal and non-lethal influenza infection and further use of these signatures in a top-down systems analysis investigating the relative pathogenic contributions of direct viral damage to lung epithelium vs. dysregulated immunity during lethal influenza infection. For acutely lethal influenza infections, the relative pathogenic contributions of direct viral damage to lung epithelium vs. dysregulated immunity remain unresolved. Here, we take a top-down systems approach to this question. Multigene transcriptional signatures from infected lungs suggested that elevated activation of inflammatory signaling networks distinguished lethal from sublethal infections. Flow cytometry and gene expression analysis involving isolated cell subpopulations fr

ORGANISM(S): Mus musculus

SUBMITTER: Marlene Brandes 

PROVIDER: E-GEOD-42639 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress