Functional genomics in perinatal asphyxia and fetal asphyctic preconditioning in the brain

ABSTRACT: Fetal asphyctic (FA) preconditioning is effective in attenuating brain damage incurred by a subsequent perinatal asphyctic insult. Unraveling mechanisms of this endogenous neuroprotection, activated by FA preconditioning, is an important step towards new clinical strategies for asphyctic neonates. Genomic reprogramming is thought to be, at least in part, responsible for the protective effect of preconditioning. Therefore, we investigated whole genome differential expression in the preconditioned rat brain. FA preconditioning was induced on embryonic day 17 (E17) by reversibly clamping the uterine circulation. Perinatal asphyxia (PA) was induced while pups were being born by caesarean section; the uterine horns, including pups, were placed in a water bath for 19 minutes. FAPA pups underwent

ORGANISM(S): Rattus norvegicus

SUBMITTER: Wouter Van Delm 

PROVIDER: E-GEOD-42676 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress