GLA and profiling of proteasome, Spt23 and Mga2
Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Pamela Silver
PROVIDER: E-GEOD-4272 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Genomic association of the proteasome demonstrates overlapping gene regulatory activity with transcription factor substrates.
Auld Kathryn L KL Brown Christopher R CR Casolari Jason M JM Komili Suzanne S Silver Pamela A PA
Molecular cell 20060301 6
The proteasome can regulate transcription through proteolytic processing of transcription factors and via gene locus binding, but few targets of proteasomal regulation have been identified. Using genome-wide location analysis and transcriptional profiling in Saccharomyces cerevisiae, we have established which genes are bound and regulated by the proteasome and by Spt23 and Mga2, transcription factors activated by the proteasome. We observed proteasome association with gene sets that are highly t ...[more]
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