Murine microenvironment metaprofiles associate with human cancer etiology and intrinsic subtypes

ABSTRACT: We developed a mouse model that captures radiation effects on host biology by transplanting unirradiated Trp53 null mammary tissue to sham or irradiated hosts. Gene expression profiles of tumors that arose in irradiated mice are distinct from those that arose in naM-CM-/ve hosts. Host irradiation induces a metaprofile consisting of gene modules representing stem cells, cell motility, macrophages and autophagy. Human orthologs of the host irradiation metaprofile discriminated between radiation-preceded and sporadic human thyroid cancers. An irradiated host centroid was strongly associated with estrogen receptor negative breast cancer. When applied to sporadic human breast cancers, the irradiated host metaprofile strongly associated with basal-like and claudin-low breast cancer intrinsic sub

ORGANISM(S): Mus musculus

SUBMITTER: David Nguyen 

PROVIDER: E-GEOD-42742 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress