Non-targeted effects of low dose ionizing radiation act via TGF-beta to promote mammary carcinogenesis

ABSTRACT: This is a genome-wide approach to identifying genes persistently induced in the mouse mammary gland by acute whole body low dose ionizing radiation (10cGy), 1 and 4 weeks after exposure. Gene expression that is modified under these parameters were compared between Tgfb1 wild type and heterozygote littermates in order to determine which genes induced or repressed by radiation were mediated via Tgfb1 status. Differential gene expression was analyzed in Tgfb1 heterozygote and wild type littermate 4th mammary glands, after whole body exposure to an acute dose of 10cGy ionizing radiation. Estrus cycle was normalized in all mice two days prior to irradiation by injection with an estrogen and progesterone mixture. It is widely believed that the carcinogenic action of ionizing radiation is due to

ORGANISM(S): Mus musculus

SUBMITTER: Mary Barcellos-Hoff 

PROVIDER: E-GEOD-18216 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress