Transcription profiling of rat Ren2 left ventricles to generate predictive heart failure expression profile

ABSTRACT: The intercalated disc of cardiac myocytes is emerging as a crucial structure in the heart. Loss of intercalated disc proteins like N-cadherin causes lethal cardiac abnormalities, mutations in intercalated disc proteins cause human cardiomyopathy. A comprehensive screen for novel mechanisms in failing hearts demonstrated that expression of the lysosomal integral membrane protein-2 (LIMP-2) is increased in cardiac hypertrophy and heart failure in both rat and human myocardium. Complete loss of LIMP-2 in genetically engineered mice did not affect cardiac development; however these LIMP-2 null mice failed to mount a hypertrophic response to increased blood pressure but developed cardiomyopathy. Disturbed cadherin localization in these hearts suggested that LIMP-2 has important functions outsid

ORGANISM(S): Rattus norvegicus

SUBMITTER: Arie van Erk 

PROVIDER: E-GEOD-4286 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress