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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of primary prostate cancer biopsies wutg different ETS transcription factor rearrangements

ABSTRACT: This work was conducted to identify shared and specific target genes of different ETS transcription factor rearrangements in prostate cancer. Potential target genes were identified by differential gene expression analysis of primary tumor samples with ETS rearrangements, and validated by ETS silencing in prostate cancer cell lines. The series consists of 50 primary tumor samples from a consecutive series of 200 clinically localized cancers treated with radical prostatectomy at the Portuguese Oncology Institute, Porto, Portugal. The series is enriched in tumors with ETS transcription factor rearrangements

ORGANISM(S): Homo sapiens

SUBMITTER: Manuel Teixeira

PROVIDER: E-GEOD-42954 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Molecular subtyping of primary prostate cancer reveals specific and shared target genes of different ETS rearrangements.

Paulo Paula P Ribeiro Franclim R FR Santos Joana J Mesquita Diana D Almeida Mafalda M Barros-Silva João D JD Itkonen Harri H Henrique Rui R Jerónimo Carmen C Sveen Anita A Mills Ian G IG Skotheim Rolf I RI Lothe Ragnhild A RA Teixeira Manuel R MR

Neoplasia (New York, N.Y.) 20120701 7

This work aimed to evaluate whether ETS transcription factors frequently involved in rearrangements in prostate carcinomas (PCa), namely ERG and ETV1, regulate specific or shared target genes. We performed differential expression analysis on nine normal prostate tissues and 50 PCa enriched for different ETS rearrangements using exon-level expression microarrays, followed by in vitro validation using cell line models. We found specific deregulation of 57 genes in ERG-positive PCa and 15 genes in ...[more]

PMID: 22904677

Publication: 1/2

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The ETS transcription factor ESE3 controls prostate epithelial cell differentiation

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Expression profiling of prostate cancer biopsies.

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| phs000310 | dbGaP

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2011-10-19 | E-GEOD-29808 | biostudies-arrayexpress

Oncogenic ETS proteins replace activated Ras/MAPK signaling in prostate cells.

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2011-06-01 | E-GEOD-26367 | biostudies-arrayexpress

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