Maternal age effect on mouse oocytes: new biological insight from proteomic analysis

ABSTRACT: The long-standing view of 'immortal germ line versus mortal soma' poses a fundamental question in biology concerning how oocytes age in molecular terms. A mainstream hypothesis is that maternal aging of oocytes has its roots in gene transcription. Investigating the proteins resulting from mRNA translation would reveal how far the levels of functionally available proteins correlate with mRNAs, and would offer novel insight into the changes oocytes undergo during maternal aging. Gene ontology semantic analysis reveals the high similarity of the detected proteome (2,324 proteins) to the transcriptome (22,334 mRNAs), though not all proteins have a cognate mRNA. Concerning their dynamics, 4-fold changes of abundance are more frequent in the proteome (3%) than the transcriptome (0.05%), with cor

ORGANISM(S): Mus musculus

SUBMITTER: Marcin Siatkowski 

PROVIDER: E-GEOD-42959 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress