Natural cardiogenesis-based template predicts cardiogenic potential of induced pluripotent stem cell lines

ABSTRACT: Rationale: Cardiac development is a complex process that results in the first integrated, multi-lineage embryonic tissue. Imperfect developmental progression leads to congenital heart disease, the most common birth defect with developmental corruption affecting more than 1% of all live births. Interrogation of individual genes has provided the backbone for cardiac developmental biology, yet a comprehensive transcriptome derived from natural cardiogenesis is required to establish an unbiased roadmap to gauge innate developmental milestones necessary for stem cell-based differentiation and in vitro disease modeling. Objective: Establish a contextual expression database of spatial-temporal cardiac structures, and validate a predictive tool to diagnose and predict cardiogenic outcomes from in

ORGANISM(S): Mus musculus

SUBMITTER: XING LI 

PROVIDER: E-GEOD-43197 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress