Antitumor activity of a pyrrole-imidazole polyamide

ABSTRACT: We report that a DNA minor groove binding hairpin pyrrole-imidazole (Py-Im) polyamide interferes with RNA polymerase II (RNAP2) activity in cell culture. Genome-wide mapping of RNAP2 binding shows reduction of occupancy preferentially at transcription start sites (TSS), while occupancy at enhancer sites are is unchanged. Genome-wide mapping of RNA polymerase II in LNCaP cells treated with DHT and DHT with Py-Im polyamide.

ORGANISM(S): Homo sapiens

SUBMITTER: Fei Yang 

PROVIDER: E-GEOD-43253 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress