IdentiM-oM-,M-^Acation of genes responsible for biosynthesis of kojic acid in Aspergillus oryzae

ABSTRACT: Kojic acid is produced in large amounts by Aspergillus oryzae as a secondary metabolite and is widely used in the cosmetic industry. Glucose can be converted to kojic acid, perhaps by only a few steps, but no genes for the conversion have thus far been revealed. Using a DNA microarray, gene expression proM-oM-,M-^Ales under three pairs of conditions signiM-oM-,M-^Acantly affecting kojic acid production were compared. All genes were ranked using an index parameter reM-oM-,M-^Becting both high amounts of transcription and a high induction ratio under producing conditions. After disruption of nine candidate genes selected from the top of the list, two genes of unknown function were found to be responsible for kojic acid biosynthesis, one having an oxidoreductase motif and the other a transpor

ORGANISM(S): Aspergillus oryzae

SUBMITTER: Maiko Umemura 

PROVIDER: E-GEOD-43280 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress