Global transcriptome analysis on Ankrd2 deficient or overexpressing differentiating primary myoblasts

ABSTRACT: To provide insights into the role of Ankrd2 in the pathways controlling myogenic differentiation, the gene networks that are disturbed in Ankrd2 knockout or overexpressing primary cells were explored during differentiation. Ankrd2 plays an important role in myogenic differentiation by modulating the activity of its interacting partners (i.e p53). Since Ankrd2 binds to numerous transcription factors many signaling pathways remained to be explored to determine the functional significance of crosstalk between Ankrd2 and the activation of transcriptional programmes that regulate muscle remodeling. In contrast to previous gene expression studies in which we and others have studied the effect of Ankrd2 silencing in mouse differentiating C2C12 cells (Series GSE7542) and human differentiated CHQ5B

ORGANISM(S): Mus musculus

SUBMITTER: Gerolamo Lanfranchi 

PROVIDER: E-GEOD-43500 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress