Regulation of the epithelial adhesion molecule CEACAM1 is essential for palate formation.

ABSTRACT: Cleft palate results from a mixture of genetic and environmental factors and occurs when the bilateral palatal shelves fail to fuse. The objective of this study was to search for new genes involved in mouse palate formation. Gene expression of murine embryonic palatal tissue was analyzed at the various developmental stages before, during, and after palate fusion using GeneChip? microarrays. Ceacam1 was one of the highly up-regulated genes during and after fusion in palate formation, and this was confirmed by quantitative real-time PCR. Immunohistochemical staining showed that CEACAM1 was expressed at a very low level in palatal epithelium before fusion, but highly expressed in the midline of the palate during and after fusion. To investigate the developmental role of CEACAM1, function-bloc

ORGANISM(S): Mus musculus

SUBMITTER: Takayoshi Sakai 

PROVIDER: E-GEOD-43651 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress