U87 cells implanted on a chick CAM (Chorioallantoic Membrane)

ABSTRACT: Glioblastoma multiforme (GBM) brain tumours have one of the shortest mean survival times (<1 year). In vivo models of GBM in mice and rats have been developed to study aspects of glioma that cannot be observed in cell culture such as angiogenesis, invasion and metastasis. Gliomas can be induced by implantation of rodent glioma cell lines into the brain or flank of nude mice. The disadvantages of rodent models however include variable growth rate and poor penetrance, which leads to difficulties in collecting clearly graded samples (pre-vascular/vascular). Bikfalvi et al have previously established a human GBM model that addresses these issues based on the chicken egg chorio-allantoic membrane (CAM), a highly vascularised extra-embryonic tissue. We have used DNA microarrays and a CAM model o

ORGANISM(S): Gallus gallus

SUBMITTER: Nil Turan 

PROVIDER: E-GEOD-43674 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress