Hepatic molecular alterations more than muscle's differentiate obese hyperphagic mice from those prolonged fed with the high-fat diet

ABSTRACT: Although mitochondrial dysfunctions are implicated in the pathogenesis of obesity, the molecular mechanisms underlying obesity-related metabolic abnormalities are still not well established. To acquire a comprehensive picture of mitochondrial molecular changes within metabolically active tissues, we focused on hepatic and muscle whole cellular transcriptome and mitochondrial proteome alterations in 16 and 48 weeks old high fat diet (HFD)-feed wild type C57BL/6J and hyperphagic, genetically modified mice with leptin dysfunction (ob/ob and db/db). On transcriptome level, the most discriminative hepatic alterations distinguished between genetically modified and wild type mice, and between overnight fasted and non-fasted mice, while the muscle transcriptional alterations related mainly to the

ORGANISM(S): Mus musculus

SUBMITTER: Krzysztof Goryca 

PROVIDER: E-GEOD-43691 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress