Microarray to find ATF5 dependent genes in response to proteasome inhibition

ABSTRACT: Environmental stresses that disrupt protein homeostasis induce phosphorylation of eIF2, triggering repression of global protein synthesis coincident with preferential translation of ATF4, a transcriptional activator of the Integrated stress response (ISR). Depending on the extent of protein disruption, ATF4 may not be able to restore proteostatic control and instead switch to a terminal outcome that features elevated expression of the transcription factor CHOP (GADD153/DDIT3). The focus of this study was to define the mechanisms by which CHOP directs gene regulatory networks that determine cell fate. We find that in response to proteasome inhibition, CHOP induces the expression of a collection of genes encoding transcription regulators, including ATF5, which is preferentially translated d

ORGANISM(S): Mus musculus

SUBMITTER: Ron Wek 

PROVIDER: E-GEOD-43714 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress