Identification of nucleosome positions at hox TSSs during zebrafish embryonic development

ABSTRACT: Nucleosome arrangement in promoter regions has been shown to play an important role in gene regulation. Genome wide studies in yeast, flies, worms, mammalian ES and transformed cell lines have found well positioned nucleosomes with an area of nucleosome depletion flanking transcription start sites. This Nucleosome arrangement has been shown to be dependent on sequence (cis-regulatory factors), DNA binding factors (trans-regulatory factors) and ATP-dependant chromatin modifiers. However, little is understood about how the nascent embryonic genome positions nucleosomes during development. This is particularly intriguing since the embryonic genome undergoes a whole scale rechromatinization event upon fusion of sperm and oocyte. Using four stages of early embryonic zebrafish development w

ORGANISM(S): Danio rerio

SUBMITTER: Steven Weicksel 

PROVIDER: E-GEOD-43757 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress