Gene expression profiling to recognize specific features of non-genotoxic carcinogens

ABSTRACT: The current test strategy for carcinogenicity is generally based on in vitro and in vivo genotoxicity assays. Non-genotoxic carcinogens (NGTXC) are negative for genotoxicity and go undetected. Therefore, alternative tests to detect these chemicals are urgently needed. NGTXC act through different modes of action, which complicates the development of such assays. We have demonstrated recently in primary mouse hepatocytes that some, but certainly not all, NGTXC can be categorized according to their mode of action based on feature detection at a gene expression level (Schaap et al. 2012 (PMID 22710402)). Identification of a wider range of chemicals probably requires multiple in vitro systems. In the current study, we describe the added value of using mouse embryonic stem cells. In this study,

ORGANISM(S): Mus musculus

SUBMITTER: Mirjam Schaap 

PROVIDER: E-GEOD-44088 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress