Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse PERK mutant vs. wild type

ABSTRACT: Molecular characterization of PERK's role in the mouse exocrine pancreas. Postnatal days 16, 19 and 32 were examined. Postnatal day 16 represents a stage immediately prior to severe cytological changes in the exPKO mice. Postnatal day 19 represents the initial stage of severe phenotypes in the exPKO mice. Postnatal day 32 represents the middle stage of severe phenotypes (about 2 wks from the initiation) in the exPKO mice. Experiment Overall Design: Comparison between the two genotypes (Perk mutant vs. wild-type) at postnatal days 16, 19 and 32.

ORGANISM(S): Mus musculus

SUBMITTER: Douglas Cavener 

PROVIDER: E-GEOD-4422 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice.

Iida Kaori K   Li Yulin Y   McGrath Barbara C BC   Frank Ami A   Cavener Douglas R DR  

BMC cell biology 20070829

<h4>Background</h4>Deficiency of the PERK eIF2 alpha kinase in humans and mice results in postnatal exocrine pancreatic atrophy as well as severe growth and metabolic anomalies in other organs and tissues. To determine if the exocrine pancreatic atrophy is due to a cell-autonomous defect, the Perk gene was specifically ablated in acinar cells of the exocrine pancreas in mice.<h4>Results</h4>We show that expression of PERK in the acinar cells is required to maintain their viability but is not req  ...[more]

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