Single-cell derived clones from human adipose stem cells present different immunomodulatory properties.

ABSTRACT: Human adipose mesenchymal stem cells are a heterogeneous population, where cell cultures derived from single cell-expanded clones present varying degrees of differential plasticity. This work focuses on the immunomodulatory/anti-inflammatory properties of these cells. To this end, 5 single cell clones were isolated (1.X and 3.X) from 2 volunteers. Regarding the expression level of the lineage-characteristic surface antigens, clones 1.10 and 1.22 expressed the lowest amounts, while clones 3.10 and 3.5 expressed more CD105 than the rest and clone 1.7 expressed higher amounts of CD73 and CD44. Regarding cytokine secretion, all clones were capable of spontaneously releasing high levels of IL-6 and low to moderate levels of IL-8. Furthermore, clone 3.X produced the highest amounts of pro-inflam

ORGANISM(S): Homo sapiens

SUBMITTER: Agustin Fernandez 

PROVIDER: E-GEOD-44222 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress