Dataset Information
LFQP of lysates from wild-type, RAB18-, TBC1D20-, RAB3GAP1- and RAB3GAP2-null RPE1 cells
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell
DISEASE(S): Warburg Micro Syndrome
SUBMITTER: 
Mark Handley
LAB HEAD: Mark Thomas Handley
PROVIDER: PXD016326 | Pride | 2024-01-26
REPOSITORIES: Pride
Publications
Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.
The Journal of biological chemistry 20230928 11
Loss of functional RAB18 causes the autosomal recessive condition Warburg Micro syndrome. To better understand this disease, we used proximity biotinylation to generate an inventory of potential RAB18 effectors. A restricted set of 28 RAB18 interactions were dependent on the binary RAB3GAP1-RAB3GAP2 RAB18-guanine nucleotide exchange factor complex. Twelve of these 28 interactions are supported by prior reports, and we have directly validated novel interactions with SEC22A, TMCO4, and INPP5B. Con ...[more]
