Maternal microRNAs secreted by the endometrium act as transcriptomic regulators of the pre-implantation embryo

ABSTRACT: The developmental origins of adult disease are now recognized to reflect intrauterine conditions during embryonic and fetal life. Cell-cell communication between the maternal endometrium and the pre-implantation embryo can occur by several means. Here, we show that maternal miRNAs are secreted by the endometrial epithelium to the endometrial fluid. Microarray assessments revealed the presence of specific miRNAs that are associated with the window of implantation and therefore in direct contact with the human preimplantation embryo. These miRNAS are transported as free or exosome-associated molecules secreted to the endometrial fluid and then uptake into the pre-implantation embryo through the trophoectoderm. Finally, these maternal miRNAsS were able to induce transcriptional and functional

ORGANISM(S): Homo sapiens

SUBMITTER: Juan Moreno-Moya 

PROVIDER: E-GEOD-44558 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress