Proteomics

Dataset Information

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Human trophectoderm extracellular vesicle proteome


ABSTRACT: Embryo implantation into maternal endometrium is critical for initiation and establishment of pregnancy, requiring developmental synchrony between endometrium and blastocyst. However, factors regulating human endometrial-embryo cross talk and facilitate implantation remain largely unknown. Extracellular vesicles (EVs) are emerging as important mediators of this process. Here, human trophectomderm stem cell-derived EVs were shown to transfer to and regulate human endometrial cells towards processes associated with implantation. Importantly, transfer of trophectoderm EV cargo proteins to endometrial cells to mediate changes in polarity is demonstrated.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Embryo, Early Embryonic Cell

DISEASE(S): Disease Free

SUBMITTER: david greening  

LAB HEAD: david greening

PROVIDER: PXD022501 | Pride | 2021-03-18

REPOSITORIES: Pride

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