Effect of allergen sensitization on gene expression in dendritic cells from neonates of asthmatic vs control mothers

ABSTRACT: This study aims to demonstrate the link between epigenome-wide methylation aberrations at birth and genomic transcriptional changes upon allergen sensitization that occur in the neonatal dendritic cells (DC) due to maternal asthma. In an in vivo model reproducing human epidemiology findings, maternal but not paternal asthma predisposes the neonate to increased asthma risk, the effect is allergen-independent and is not genetic or environmental. Earlier we demonstrated that neonates of asthmatic mothers are born with a functional skew in splenic DCs that mediates the early-life asthma origin. These allergen-naive cells convey allergy responses to normal recipients, however minimal to no transcriptional or phenotypic changes were found to explain the functional pro-allergic alterations. In th

ORGANISM(S): Mus musculus

SUBMITTER: Lester Kobzik 

PROVIDER: E-GEOD-44678 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress