PKC Activation Induces Inflammatory Response and Cell Death in Human Bronchial Epithelial Cells

ABSTRACT: A variety of airborne pathogens can induce inflammatory responses in airway epithelial cells, which is a crucial component of host defence. However, excessive inflammatory responses and chronic inflammation also contribute to different diseases in the respiratory system. We hypothesized that the activation of protein kinase C (PKC) is one of the essential mechanisms of inflammatory responses in airway epithelial cells. In the present study, we stimulated human bronchial lung epithelial (BEAS-2B) cells with phorbol ester Phorbol 12, 13-dibutyrate (PDBu), and examined gene expression profile with microarray analysis. Bioinformatics suggested that PKC activation induced dramatic changes in gene expression related to multiple cellular functions. The top two functional networks of genes were

ORGANISM(S): Homo sapiens

SUBMITTER: Ricardo Zamel 

PROVIDER: E-GEOD-44747 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress