Genome-wide analysis of muscle gene expression in response to an intense cycling exercise. Effect of two protein-leucine enriched diets

ABSTRACT: Protein-leucine supplement ingestion following strenuous endurance exercise accentuates skeletal-muscle protein synthesis and adaptive molecular responses, but the underlying transcriptome is uncharacterized. In a randomized single-blind triple-crossover design, 12 trained men completed 100 min of high-intensity cycling then ingested either 70/15/180/30g protein/leucine/carbohydrate/fat (15LEU), 23/5/180/30g (5LEU) or 0/0/274/30g (CON) beverages during the first 90 min of a 240-min recovery period. Vastus lateralis muscle samples (30 and 240-min post-exercise) underwent transcriptome analysis by microarray followed by bioinformatic analysis. Gene expression was regulated by Protein-leucine in a dose-dependent manner impacting the inflammatory response, muscle growth and development. At 30

ORGANISM(S): Homo sapiens

SUBMITTER: Frederic Raymond 

PROVIDER: E-GEOD-44818 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress