Anchoring ethinylestradiol induced gene expression changes with testicular morphology and reproductive function in the medaka

ABSTRACT: This study assessed the implications of a 14 day sub-chronic exposure of ethinylestradiol (EE2; 1.0 or 10.0 M-BM-5g/L EE2) on male medaka fertility, testicular histology and testicular gene expression. The findings demonstrate that a 14 day exposure to EE2 induced impaired male reproductive capacity and time- and dose-dependent alterations in testicular morphology and gene expression. The average fertilization rate/day following the exposure for control, 1.0 and 10.0 M-BM-5g/L EE2 was 91.3% (M-BM-14.4), 62.8% (M-BM-18.3) and 28.8% (M-BM-15.8), respectively. The testicular morphologic alterations observed include increased germ cell apoptosis, decreased germinal epithelium and thickening of the interstitium. The morphologic changes observed were highly associated with gene expression change

ORGANISM(S): Oryzias latipes

SUBMITTER: Hilary Miller 

PROVIDER: E-GEOD-44859 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress